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Assignment:
1. In Infrared neural stimulation and inhibition using an implantable silicon photonic microdevice.
A scientist describes and apply a device that inhibits neural activity (action potential firing) in vivo. The scientist suggest that this effect is mediated by temperature elevation and acts through activation of temperature sensitive ion channels such as those in the TRP family. What if that this is not the mechanism of action and that, instead, IR light absorption causes temperature-independent decrease in monocarboxylate transporter (MCT) efficiency.
Design experiments to test the hypotheses
2. Infrared neural inhibition is temperature independent and works via increased MCT efficiency only.
Explain a) the measurement methods you would use to test your hypothesis,
(b) the necessary experimental and control groups, and
(c) the analysis methods you would use to generate interpretable data
In analysing your favourite protein, you have carried out an indirect immunofluorescence experiment on mammalian cells
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