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1) The E. coli gene lacYencodes a protein called lactose permease, needed for digestion of lactose. A mutation in this gene at codon 64 changed the normalglycine codon into a valine codon. The mutant protein isnon-functional. However, function is restored by a second mutationthat changes codon 50 from an alanine codon to a threonine codon.Are the following terms appropriate or inappropriate to describethis second mutation? Briefly explain each answer.
a. Reversion
b. Intragenic suppressor
c. Intergenic suppressor
d. Missense mutation
There is 2-possible ways of inserting a gene into E.Coli that functions in converting a waste into an energy source.
This is "new methylene blue" stained blood. What cell is stained? What are the "inclusion bodies" called in this case of thalassemia? Describe this slide (is it peripheral blood smear/bone marrow aspirate or biopsy, and is it normal/abnormal?).
No structures needed but show all the substrates involved in each reaction and the name of the enzyme. Changed mechanism of the transmission of infectious bacterial diseases with examples.
What is the diploid chromosome number in humans and Where in the body could you find a cell with the diploid number of chromosomes?
With the completion of the human genome and the identification of various genes, it may be possible to determine whether an individual has a particular disease.
Examine of the bases of a sample of nucleic acid yielded these percentages: A= 20%, G= 30%, C= 20%, T= 30 percent. Explain why is the sample single stranded DNA.
BIOL 6150 home work, Linkage disequilibrium and LOD score, Assume the disease genotype is known, as A is the disease allele and a is the normal allele. The marker has four alleles (1, 2, 3,4).
What is the key difference between Mendel's principle of segregation and independent assortment?
What would be the phenotype expected of lac I-d mutants? (effect on gene regulation, whether it would be cis or trans acting or dominant/recessive to the wild type repressor)
In rabbits, black hair is dominant to brown at an autosomal locus, while the sex-linked recessive allele "a" is epistratic to black or brown, causing white fur. A white male was bred twice.
The pituitary gland secretes thyroid-stimulating hormone (TSH), which stimulates the thyroid gland to secrete the thyroid hormone (TH). TH has a negative feedback influence on TSH.
if a test cross of AaBb produces equal numbers of AaBb, Aabb, aaBb, and aabb progeny, what can you conclude about the map distance between the two loci?
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