Define aspirin''s mode of action is to make a covalent bond

Reference no: EM13171109

Aspirin's mode of action is to make a covalent bond with the active site of the COX II enzyme which inactivates the enzyme. A nucleophilic histidine side chain (1H-imidazolide) in the enzyme's active site forms an amide bond by acting with ester functionality on aspirin. Draw a complete, step-wise curved arrow mechanism for how this action occurs.

Reference no: EM13171109

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