Creating the different haplotypes

Assignment Help Biology
Reference no: EM1389397

Question: A rare autosomal recessive disorder causes pink hair. A non-carrier male and an affected female marry. Consider the following pedigree and RFLP analysis prepared using HindIII, Southern blot, and a probe with a human sequence known to hybridize to sequences closely linked to the gene responsible for this disorder.
a. Diagram each of the different haplotypes (group of markers that tend to be transmitted together because of linkage) of I-1 and I-2 showing the restriction map and fragment lengths. Show all HindIII restriction sites on each map.
b. On the restriction map, indicate the area to which the radioactive probe must hybridize in order to detect the fragments seen by Southern analysis.
c. To which haplotypes (essentially pattern of each chromosome) does the mutant allele of the gene seem to be linked in this family.
d. Why does individual III-1 only show one band in the RFLP analysis?
e. Which individuals are probably carriers?

Reference no: EM1389397

Questions Cloud

Centralized approach- decentralized approach : global approach; local approach. local approach; global approach. functional approach; network approach. centralized approach; decentralized approach
Statement regarding null hypothesis : Which of the following statements is not true of the null hypothesis? A) It is your theory B) It is what you would expect by chance alone C) Assumes things to be equal D) None of the above
Determine minimum number of tapes needed for backups : Days of the week (including the weekend), determine the minimum number of tapes needed to accommodate seven days worth of backups?
Explain how siemens got into criminal difficulties : Explain how Siemens got into criminal difficulties, the laws they violated also the steps they took to reform their corporate culture.
Creating the different haplotypes : A rare autosomal recessive disorder causes pink hair. A non-carrier male and an affected female marry. Think about the following pedigree and RFLP analysis prepared using HindIII.
The promotion comes with a fifty percent increase in pay : Jennifer is eligible for a promotion in twelve months; the promotion comes with a 50 percent increase in pay and 25 percent bonus. She is competing with three other employees for the position
Identify two areas where the internet as affected the law : Identify two areas where the internet as affected the law regarding either contract law, employment law, or intellectual law?
Small bags distribution to wholesalers : A flour mill produces flour in small bags before distributing them to wholesalers. The average weight of each bags is 8 kg with a standard deviation of 0.5 kg.
Write program to compute summation of four grades : when user press, the program computes summation of four grades (Grade1+Grade2+Grade3+Grade4) and print the result in the picture box (picSum).

Reviews

Write a Review

Biology Questions & Answers

  Immune response to infectious disease

It is a very curcial concept to understand how the immune response is mounted against viruses, bacteria, protozoans and helminthes. For an effective immune response, both innate and adaptive immunity should work together.

  A review on advanced glycated end products (ages)

This Project report elaborates a critical review of important elements attached to Advanced Glycated End Products (AGEs). It is very crucial to understand the process called Millard reaction.

  Plastic as a soil stabilizer

Soil stabilization is the permanent physical and chemical alteration of soils to enhance their physical properties. Stabilization can increase the shear strength of a soil and control the shrink-swell properties.

  Principles of microbiology

This assignment has three parts which contains questions related to Microbiology. It contains basic principles of microscopy, staining techniques in microbiology and microbial growth in the food industry.

  List the biologic functions

Lipid metabolites are often seen as key elements in cellular signaling. Is this unique? Please provide several examples of the function of lipids as key elements in signal arrays and list the biologic functions these signals affect?

  Biologic function relationships

Please describe how one might search for chemical structure, biologic function relationships, involving small molecular weight lipophylic compounds. Provide one example.

  Case study on patient in the haematology laboratory

Write a case study which detailing a scenario of a patient being investigated in the Haematology laboratory.

  Use of pcr and genetic approaches in biotechnology

The use of PCR and genetic approaches in biotechnology

  Describe the role of this enzyme in honey

Glucose oxidase is an enzyme that can be used for measurements of glucose levels by combining this reaction with an oxygen probe.

  Genetic problems

What phenotypic ratio would you get if you crossed a white mouse and a heterozygous brown mouse?

  Prepare an essay on nosocomial infection

Prepare an essay on nosocomial infection.

  Monitoring and recording the blood pressure

To increase the awareness of monitoring and recording the blood pressure of patients and practice measuring blood pressure in a safe environment.

Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd