Create an ice scatterplot

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Reference no: EM1367282

Required to conduct PSA using the decision-tree from the Patel case study (i.e. the rotavirus vaccination case study). Please follow the instructions below to modify your model, conduct PSA and answer the questions.

Step 1. Modify the tree model

Run the model and note your base case results.  Based on a Tornado Diagram from the model, we have selected important variables for PSA.  (You do not need to run the Tornado analysis).  Please convert these variables to distributions.  The distribution type and input parameters are reported in Table 1 below.Calculate the likeliest values.  (Hint: μ = [(a + b + c)/3]

Step 2. Calculate the ICER again

After completing the new tree, report your base-case ICER in Table 2- hint: set Preference as Cost-Effectiveness, then Analysis >> Cost-Effectiveness. 

Step 3. Conduct PSA and report the results.  Use: 10,000 iterations with baseline: current practice & comparator: national program

a. Create an ICE scatterplot (turn in).

b. Explain your scatterplot.Which quadrant do most of your iterations fall into?What does this mean?

c. Plot the ICER distribution graph (turn in).

d. Report the ICER distribution statistics in the Table 3 below. 

e. Explain your graph.

f. Plot the acceptability curves with a willingness to pay of $20,000 (turn in).

g. If the WTP in Pakistan is 6000 $/death averted, what is the probability that the national program will be cost-effective? What if the WTP is 10000 $/death averted?

h. Explain the figure in general terms.  

Table 1. Variables and distributions for the PSA






 

Variable Name

Description

Baseline

Distribution

Min

Max

likeliest

Epidemiology inputs







pRVInfected

RVGE cumulative incidence for 5 years

0.663

Triangular

0.5

0.9

 

pDieOfRVGE

RVGE case-fatality ratio

0.006

Triangular

0.001

0.01

 

pEfficacy

Vaccine Efficacy

0.483

Triangular

0.223

0.661

 

pCurVaccineCoverage

Current rotavirus vaccine coverage

0.06

Triangular

0.01

0.1

 

pExpVaccineCoverage

Expected vaccine coverage (national programs)

0.85

Triangular

0.65

1

 

pHomeCare

Patients get home care

0.888

Triangular

0.7

1

 

pFormalOutpatient

Among those with formal care, the proportion of getting outpatient care

0.6875

Triangular

0.5

0.9

 

Cost Inputs






 

cUnitVaccine

Unit cost for the vaccine

5

Triangular

1

7.5

 

cHospitalization

Hospitalization cost (4-day stay)

33.4

Triangular

25.05

41.75

 

Table 2. PSA Results

Strategy

Cost

Incr Cost

Effectiveness

IncrEff

ICER

Current practice

 

 

 

 

 

National Program

 

 

 

 

 

Are the results the same from the model prior to your entering the distributions? 

Table 3: PSA ICER results

 

Mean

SD

Median

95% Confidence Intervals

2.5%

97.5%

ICER

 

 

 

 

 

Reference no: EM1367282

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