Converted to nucleotides and incorporated into nucleic acid

Reference no: EM13234488

Several artificial nitrogenous bases, called base analogues, can be taken up by cells, converted to nucleotides, and incorporated into nucleic acids. They are often potent mutagens, and some are used in cancer chemotherapy. Two such analogues are 5-bromouracil (5-BU), and 2-aminopurine (2-AP).

a) Draw 5-BU and 2-AP and show their bonding to the bases they are most likely to pair with

b) Draw tautomers for both bases. Under physiological conditions most of the bases exist as keto (amino) tautomer, but in 5-BU the bromine group shifts the equilibrium toward an enol form. Show how this shift might cause 5-BU to pair with the purine that you would not choose as most likely in part a).

Reference no: EM13234488

Questions Cloud

What is inventory management : What is inventory management? Is inventory management really any more than just counting what is available in the warehouse and reporting that to operations? It's a matter of buying more when you are short, and holding what you have for an emergen..

Select the element with the more negative : Choose the element with the more negative (more exothermic) electron affinity from each of the following pairs.

What is the average force exerted by the wall on the ball : A 2.78-kg steel ball strikes a massive wall at 10.0 m/s at an angle of ? = 60.0° with the plane of the wall, what is the average force exerted by the wall on the ball

Napoleon is seen by many as military dictator-pure-simple : Napoleon is seen by many as a military dictator, pure and simple. Others point to Napoleon’s legacy as a lawgiver, statesman, master negotiator, and suggest that his positive effects on Western society far outweigh the damage wrought by his campai..

Converted to nucleotides and incorporated into nucleic acid : Several artificial nitrogenous bases, called base analogues, can be taken up by cells, converted to nucleotides, and incorporated into nucleic acids. They are often potent mutagens, and some are used in cancer chemotherapy.

Discuss the challenges faced by managers : Discuss the challenges faced by managers when identifying the strategic initiatives the company must pursue to achieve its goals and prioritizing the goals.

What roles did religion and economics play in their policies : Compare and contrast how Spain and the Ottoman Empire governed the peoples they conquered in the period 1500-1700. What roles did religion and economics play in their policies?

Principles of human resource planning : How are Human Resource Departments responding to the challenge of SHRM and outline the main principles of human resource planning.

Calculate the p-value for the estimate of slope : Consider a model of the influence of the average number of cigarettes the mother smoked per day during pregnancy on infant birth weight. The following simple regression model was estimated with data on n = 1388 births.

User Account

All Pages