Conduct a blastn search of your chosen gene

Reference no: EM133729048

Case: Background Scenario

You are working in neurodegenerative diseases research and found a gene linked to a specific neurodegenerative disease, you would like to find out more information about this gene, the protein it codes, the subcellular location of the gene, and etc. You are also interested to find whether there are other genes in humans similar to the one you found, if yes, what is the function? You would then like to find whether there are similar genes in other animals, so you can potentially use those animals as a model to study the gene you found.
Instructions

Please perform a search of a specific neurodegenerative disease in human (Alzheimer's disease (AD), Parkinson's disease (PD), Prion disease, Motor neurone diseases (MND), Huntington's disease (HD), Spinocerebellar ataxia (SCA), Spinal muscular atrophy (SMA)) at OMIM, then find a gene of your interest. Please record the name and chromosome location of the gene you select, as well as Phenotype MIM number of your search.

CONDUCT A SEARCH OF YOUR CHOSEN GENE AT NCBI DATABASE, AND FIND THE ACCESSION NUMBER OF THE GENOMIC DNA, MRNA AND PROTEIN RELATED TO THE GENE.
By using uniprot, please find the subcellular location, expression and the number of isoforms for the protein coded by that gene.

Please conduct a BLASTN search of your chosen gene, and restrict database to humans, can you find any paralogs of the gene? If yes, how many?

Please conduct a BLASTN search of your chosen gene, and restrict database to Saccharomyces cerevisiae, Drosophila melanogaster or Rattus norvegicus. Can you find orthologs in these species? If yes, which one of the species have the highest similarity to humans?

Please conduct a BLASTP search of your chosen protein, and restrict database to humans, can you find any paralogs of the protein? If yes, how many?

Reference no: EM133729048

Questions Cloud

Which is true regarding nps functioning in this regard : Some nurses may choose to act as advocates at the state and federal level regarding healthcare-related. Which is true regarding NPs functioning in this regard?

How did fema help people prepare for the disaster : How did FEMA help people prepare for the disaster? What services did FEMA provide to the community? Who else participated in the disaster relief efforts?

Which diagnosis best fits the presentation : A 24-year-old male graduate student is brought to the urgent care. He describes starting to feel odd about 3 month. Which diagnosis best fits this presentation?

In which phase of action research process is nina engaged : Nina is engaged in the action research process for a study that considers the role. In which phase of the action research process is Nina currently engaged?

Conduct a blastn search of your chosen gene : Conduct a BLASTN search of your chosen gene, and restrict database to humans, can you find any paralogs of the gene? If yes, how many?

Which phase of the action research : She is sharing her findings with other teachers and paraprofessionals. Aggie is now likely engaged in which phase of the action research?

Would you prefer the california or the north dakota model : Do you think you would be better represented by a state senator or state senator who has fewer people.

Describe your level of competency for conducting systematic : Describe your level of competency for conducting a systematic search of the literature to answer the clinical question.

What are the effects on her blood pressure and blood flow : She is sweating profusely and not drinking adequately. She begins to feel faint due to dehydration. What are the effects on her blood pressure and blood flow?

User Account

All Pages