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The following was measured for the time response of the Minute Ventilation (in liters/minute) for placebo, intravenous morphine, and intrathecal morphine treatments.
Hours
Placebo
Intravenous
Intrathecal
0
38
34
30
1
35
19
23.5
2
42
16
20
4
35.5
13.5
6
17
10
8
34.5
11
37.5
24
13
12
41
19.5
One method of reporting these results is to compute the "Overall Effect" which is the area under the curve divided by the total time interval (weighted average).
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