Reference no: EM133297173

1. Regarding the descriptor selection in applying QSAR to screen drugs, which statement is NOT correct?

Select descriptors that contained non-redundant information

Select as small and informative subset of descriptors as possible

Genetic algorithm can be used in molecular docking and descriptor selection

Select the more descriptors, the better

2. Which two statements about homology modeling are correct? select all that apply.

In homology modeling, the protein with sequence and structure may serve as a "template" protein.

In homology modeling, the protein with only sequence but no structure is called our "template" protein.

In homology modeling, there is no need to use proteins with 3D structure during structure prediction

In homology modeling, the protein with only sequence but no structure is called our "target" protein.

3. Regarding protein conformational energy

A. Lower energy conformation means the conformations are more stable

B. More stable protein conformations are more popular conformations

4. Which statement(s) above is(are) correct?

Statement A only.

Statement B only.

Both Statement A and B are correct.

Both Statement A and B are incorrect.

5. Which one is NOT the advantage of applying computational/bioinformatics methods in drug discovery?

It is possible to investigate compounds which do not exist yet.

All compounds must be synthesized first.

It is helpful to design and modify hits and leads.

It is usually low costs

One can design ligands in computer.