Compare vitro and in vivo models of secondary haemostasis.

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Assignment:

A 22-year-old female patient has had recurrent gum bleeding for many years associated with menorrhagia since menarche. Her mother and brothers experience gum bleeding and epistaxis for many years. Investigations reveal Haemoglobin 7.4g/dl, WBC 12 x 109/L, Platelet 312 x 109/L; PT 14.5 sec (control 1 1.2 sec), PTT 52 sec (control 33 sec).

Discuss the patient's family history, with particular reference to the pattern of inheritance.
Compare the in vitro and in vivo models of secondary haemostasis.
Describe the routine tests for the assessment of secondary haemostasis and include the possible sources of error. Comment on the patient's laboratory results.

Reference no: EM133422824

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