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Question: Multiple Myeloma One treatment for multiple myeloma (cancer of the blood and bones) is a stem cell transplant. However, in some cases the cancer returns. McCarthy and colleagues reported on a study that randomly assigned 460 patients (100 days after a stem cell transplant) to receive either lenalidomide or placebo. At one point in the study, 46 of the patients who received the real drug had a bad result (had progressive disease or had died), compared to 101 of those who received the placebo. Assume that exactly half were assigned to each group.
a. Find and compare the percentages that had a bad result for the two groups.
b. Test the hypothesis that the drug reduced the chance of a bad result compared to the placebo using a significance level of 0.05.
c. The study started in April 2005 and was "unblinded" in 2009 when an interim analysis showed better results with the group taking the drug. After the unblinding, many of the patients from the placebo group "crossed over" to the drug group. Explain what you think "unblinding" means and why this seems like a reasonable thing to do.
Don't catch a cold! A recent study of 1000 students at the University of Michigan investigated how to prevent catching the common cold.
X has a normal distribution with a mean of 80.0 and a standard deviation of 3.5. Find the following probabilities:
suppose the following data are selected randomly from a population of normally distributed values.44 51 43 48 45 57 54
Explain this result (including the underlying logic of the computations) to a person who understands hypothesis testing involving a single sample and a known population, but knows nothing about t tests.
Using the t tables, software, or a calculator, estimate the critical value of t for a 95% confidence interval with df = 7.
a golf ball is selected at random from a golf bag. if the golf bag contains 1 green balls6 brown balls and 8 orange
What is the expected number of audits for the 6 randomly selected individuals? What is the standard deviation for the number of audits for the 6 randomly selected individuals?
Aanalyze it by constructing appropriate plots and numerical summaries,- describe the key features of the data in words.
Determine whether the following definitions are stipulative, lexical, precising, theoretical, or persuasive.- "Gene" means the hereditary unit that occupies a fixed chromosomal locus, which through transcription has a specific effect on phenotype an..
(Classical Probability) Fission occurs when the nucleus of an atom captures a subatomic particle called a neutron and splits into lighter nuclei. This causes energy to be released. At the same time other neutrons are emitted, two or three on the a..
For each question, find the area to the right of the given z-score in a standard Normal distribution. In this question, round your answers to the nearest 0.000.
With the test statistic you chose, work out the problem with solution using .05 level of significance if it applies.
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