Compare and contrast the procaryotic replication fork

Reference no: EM133393480

Questions:

1) Compare and contrast the procaryotic replication fork with the eucaryotic replication fork. What are the similarities and differences between the two? Concentrate your discussion on the polymerases involved, the structure and mechanisms of leading and lagging strand synthesis, and the role of the sliding clamp.

2) Explain why DNA synthesis is coupled to the hydrolysis of pyrophosphate.

3) Describe the process of transcription-coupled nucleotide excision repair. Predict the immediate consequences to a cell in which this process stopped functioning properly.

4) Explain why the deamination of 5-methyl-cytosine in DNA leads to hot spots for spontaneous mutations more than the deamination of cytosine.

5) Translesion synthesis allows replication passed damage to DNA bases. Explain the following: (a) how translesion polymerases can get passed damaged DNA bases whereas replicative DNA polymerases cannot, and (b) the role of PCNA in switching the replicative DNA polymerases with the translesion DNA polymerases.

Reference no: EM133393480

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