Reference no: EM133747315
Summarize Unlikely if treatment duration has been less than 4 weeks
• Abrupt discontinuation of high doses may cause a syndrome consisting of somatic symptoms: Dizziness (exacerbated by movement), lethargy. nausea, vomiting, diarrhea, headache, fever, sweating, chills, malaise, incoordination, insomnia, vivid dreams; neurological symptoms: Myalgia, paresthesias; "electric-shock-like" sensations, dyskinesias, visual discoordination; psychological symptoms: Anxiety, agitation, crying, irritability, confusion, slowed thinking, disorientation; rarely aggression, impulsivity, hypomania, and depersonalization; cases of mania reported following antidepressant taper, despite adequate concomitant mood-stabilizing treatment
• Brain "zaps" (or electric-shock-like sensations), often associated with lateral eye movements, hearing static sounds, and feelings of dizziness/ wooziness; occur most commonly with abrupt discontinuation of citalopram, escitalopram, paroxetine, and sertraline; usually transitory but may last for months • Most likely to occur within 1-7 days after a short half-life drug is stopped or dose drastically reduced, and typically disappears within 3 weeks although cases of symptoms persisting for up to 1 year have been reported
• Reintroduction of treatment results in improvement of symptoms in 2-3 days
• Incidence (of 2-78%) is related to half-life of antidepressant - reported most frequently with paroxetine, least with fluoxetine; attributed to rapid decrease in 5-HT availability. With paroxetine, discontinuation symptoms may also
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