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You manage a lab that studies cancer formation and find some interesting results. You are testing levels of gene expression for Rb1 in normal vs. cancerous cells and find that the mRNA levels detected by microarray are the same. However, when you measure the functional level of the protein RB1 (made from the Rb1 gene) you find that cancerous cells have ten times more functional protein than normal cells.
Using your textbook and other resources (like the article linked above) describe one gene control mechanism that could lead to these results. (10 marks)
Note: Your answers don't need a lot of molecular detail. Briefly describe how the gene control mechanism works and link that to how it would lead to the results above. Your answer should also relate your description back to what we've learned about how you go from a gene to a functional protein (though it may go beyond that if you like).
Training return on investment (ROI) is a calculation of economic return on a project. Refer to the lecture for the formula. Review this problem.
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Select one of the publicly traded corporations listed below and obtain the most current SEC Form 10-K (annual financial report) from the company's web site
Solve these four problems incorporating present value analysis relative to investment decisions in this exercise.
Consider a 3.60 percent TIPS with an issue CPI reference of 185.8. At the beginning of this year, the CPI was 193.3 and was at 199.8 at the end of the year.
Explain the models, strategies, and competencies needed to facilitate change.
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