Reference no: EM133296853

Question 1.

Bisphosphonates can be used as a treatment for a range of illnesses.

Critically analyse the use of bisphosphonates as a treatment for one illness. Ensure you explicitly state the illness you are discussing. The analysis should include discussions on the specific benefits and limitations of using bisphosphonates as a treatment option for that illness, with reference to the mechanisms of action.

Neglected tropical diseases/ Illnesses such as chagas disease and leshmaniasis

Question 2.

a) With respect to the following antiparasitic agents, provide details of their mechanism of action and reasons for the development of drug resistance.

(i) Chloroquine

(ii) Mebendazole

(iii) Monepantel

b) Multi-drug resistant parasitic nematodes are becoming increasingly prevalent.

(i) Summarise an experimental approach that would allow you to determine the likely causes of multi-drug resistance in a parasitic nematode.

(ii) What are the likely changes that underpin the multi-drug resistance status of the parasite?

c) Outline a strategy that utilises the free-living nematode Caenorhabditis elegans to assist development of novel anthelmintics and/or nematicides.