Bidirectional associative synaptic modification driven

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In 1977, Terry Sejnowski developed the first mathematical model for bidirectional associative synaptic modification driven by the proportion of coincident and anti-coincident spiking activity as part of a proposed competition between the timing of inputs. He called it the "time-dependent non-linear model" and proposed that "...the change in synaptic strength is proportional to the covariance between discharges of the parallel and climbing fiber:then the synapses increases in strength when the discharges are positively correlated, decreases in strength when the discharges are negatively correlated, and maintains a constant average strength when the discharges are uncorrelated."(Sejnowski, 1977b).

If we are looking at the modifications made based on the correlation of discharge, are we allowing the maintenance of a constant average strength because a lack of association/correlated discharge would not weaken the relationship between two units, it would just be unaffected?

Reference no: EM132486798

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