Assess the physiological effects of the mutation you studied

Assignment Help Biology
Reference no: EM133383014

Case Study: Many diseases which affect the cardiovascular system result from ion channel mutations. One example of this is Timothy syndrome where a mutation (G406R) in the alpha-subunit of L-type Ca2+ channels alters the inactivation properties of the L-type current which can lead to long QT syndrome and potentially fatal arrhythmia

In a computer practical a programme was used to simulate ionic currents in two cell lines, one of which expresses wild-type L-type channels and the other is expressing a mutant L-type channel which was suspected to have similar properties to the G406R mutation that causes Timothy syndrome. The task in the computer practical was to examine and measure some of the properties of this mutant and compare these with the wild-type current.

QUESTION: Suggest further experiments that could be done to assess the physiological effects of the mutation you studied, in the computer practical, on the heart.

 

Reference no: EM133383014

Questions Cloud

Patient complaint of dyspnea : What questions to ask during HPI/ROS and what do exam during the Physical Assessment for a patient complaint of dyspnea.
What is the magnitude and direction of the net force : What is the magnitude and direction (up or down) of the net force acting on the glass? What is the magnitude of the upward force (F1) you are applying
The meta-analysis contains the data and graphs : The systematic review contains the narrative portion, and the meta-analysis contains the data and graphs
Brochure regarding adverse effects of montelukast : What information will the students include in the brochure regarding the adverse effects of montelukast?
Assess the physiological effects of the mutation you studied : Suggest further experiments that could be done to assess the physiological effects of the mutation you studied, in the computer practical, on the heart.
Build your skills for the successful completion : Provide a specific and concise tentative title for your literature review paper (You may use the results or at least the variables in the title)
Global nutrition deficiencies-mental healthcare barriers : Can you explain a short introduction on global nutrition deficiencies, mental healthcare barriers, and healthcare sustainable development
How exactly does the buffer system in the body work : How exactly does the buffer system in the body work and are bicarbonate just the name for the c02 that's stored in the ICF and ECF?
Presyncope and mild exertional chest pain : Mr. Jim Nichols, a 67-year-old male presents with complains of dyspnea on exertion, presyncope, and mild exertional chest pain.

Reviews

Write a Review

Biology Questions & Answers

  Immune response to infectious disease

It is a very curcial concept to understand how the immune response is mounted against viruses, bacteria, protozoans and helminthes. For an effective immune response, both innate and adaptive immunity should work together.

  A review on advanced glycated end products (ages)

This Project report elaborates a critical review of important elements attached to Advanced Glycated End Products (AGEs). It is very crucial to understand the process called Millard reaction.

  Plastic as a soil stabilizer

Soil stabilization is the permanent physical and chemical alteration of soils to enhance their physical properties. Stabilization can increase the shear strength of a soil and control the shrink-swell properties.

  Principles of microbiology

This assignment has three parts which contains questions related to Microbiology. It contains basic principles of microscopy, staining techniques in microbiology and microbial growth in the food industry.

  List the biologic functions

Lipid metabolites are often seen as key elements in cellular signaling. Is this unique? Please provide several examples of the function of lipids as key elements in signal arrays and list the biologic functions these signals affect?

  Biologic function relationships

Please describe how one might search for chemical structure, biologic function relationships, involving small molecular weight lipophylic compounds. Provide one example.

  Case study on patient in the haematology laboratory

Write a case study which detailing a scenario of a patient being investigated in the Haematology laboratory.

  Use of pcr and genetic approaches in biotechnology

The use of PCR and genetic approaches in biotechnology

  Describe the role of this enzyme in honey

Glucose oxidase is an enzyme that can be used for measurements of glucose levels by combining this reaction with an oxygen probe.

  Genetic problems

What phenotypic ratio would you get if you crossed a white mouse and a heterozygous brown mouse?

  Prepare an essay on nosocomial infection

Prepare an essay on nosocomial infection.

  Monitoring and recording the blood pressure

To increase the awareness of monitoring and recording the blood pressure of patients and practice measuring blood pressure in a safe environment.

Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd