Arrangement of the amino acids in teh catalytic triad

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Reference no: EM13256794

AChE contains a catalytic triad with the residues His, Glu, and Ser. The nerve agent sarin is an extremely potent inactivator of AChE. Sarin irreversibly inhibits AChE by covalently modifying the serine residue in the active site.

a. Diagram the expected arrangement of the amino acids in teh catalytic triad

b. Draw a mechanism for the covalent modification of AChE by sarin.

Reference no: EM13256794

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