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Argatroban and bivalirudin have a labeled use for: (a) primary prevention of DVT (b) lysis of thrombi in patients having ST-segment elevation MI (c) treating patients undergoing PCI who have HIT (d) adjunctive therapy during fibrinolytic therapy for acute ischemic stroke 24. Argatroban is used prophylactically to prevent thrombosis in patients who: (a) are having hip or knee surgery (b) are receiving fibrinolytic therapy for ST-segment elevation MI (c) are receiving aspirin as a secondary prevention against stroke (d) have HIT 25. Dabigatran is used to treat: (a) patients undergoing PCI who have HIT (b) patients who are having a non-ST-segment elevation MI (c) patients who are resistant to warfarin (d) patients who have DVT or PE 26. The basic mechanism of action of fondaparinux is: (a) inhibition of platelet activation and aggregation (b) inhibiting the activity of factor Xa (c) decreasing the synthesis of clotting factors (d) inhibiting the activity of glycoprotein receptors 27. Fondaparinux has a labeled use to treat: (a) acute DVT or PE, in conjunction with warfarin (b) HIT (c) non-valvular atrial fibrillation (d) patients at high risk for ischemic stroke.
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