Reference no: EM133178570

Therapeutic Targeting in Cancer

Level 7

Aim: To gain an understanding of anti-cancer therapies, their applications to specific cancer types and personalised cancer medicine, and mechanisms of resistance.

Learning Outcome 1: Critically evaluate published scientific literature and demonstrate comprehension of current scientific knowledge.

Learning Outcome 2: Justify therapeutic regimens and relate these to oncogenic driver mutations and the Hallmarks of Cancer across a wide range of cancers.

Learning Outcome 3: Communicate published clinical and scientific data in both written and oral formats.

Indicative Content

Chemotherapy-based approaches.
Radiotherapy-based approaches (external beam radiotherapy, brachytherapy, radioisotope therapy)
Use of biomarkers in drug discovery and target identification
Biopharmaceutical-based targeted therapies including immunotherapies and targeting of receptor tyrosine kinases
Small molecule-based targeted therapies (proteasome inhibitors, HDAC inhibitors, Tyrosine kinase inhibitors and Ras/Raf/Erk inhibitors)
Acquired drug resistance mechanisms and clonality
Immunotherapy (PD1/PD-L1 axis, CAR-T cells)
Photodynamic therapy
Vascular-targeted therapies

Students will focus on the typical therapeutic approaches applied to a specific tumour type in the coursework and apply knowledge of a wide range of major therapeutic strategies to a broader range of clinical setting in the exam.

comprise a poster presentation based around the treatment regimens limited to a single tumour type, and how these therapies target the most relevant Hallmarks of Cancer. Students will critically appraise current literature, identify and select the most relevant strategies, and present the poster in a ‘mini-conference'. The poster will encourage students to engage with all major treatments (chemotherapy, radiotherapy, targeted therapy and others if applicable) for the given tumour type and summarise specific therapies for specific sub-types. As part of the assessment, students will be questioned on their working knowledge of the poster content.

Attachment:- Therapeutic Targeting.rar