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Assume you have been examining a new drug that binds to PPAR? and produces its beneficial effect (increased insulin sensitivity). When you give this chemical to mice, you see kidney damage. Other PPAR? drugs did not lead to the same toxic effect and in a PPAR? knockout mouse you still see kidney damage. However, the type of damage that you see resembles drugs that affect another receptor called ROR. When ROR is knocked out in mice, you no longer see kidney damage, but you still see the beneficial effects. Which of the following is correct?
A) ROR is the ontarget receptor and PPAR? is the offtarget receptor
B) ROR is the offtarget receptor and PPAR? is the ontarget receptor
C) ROR activation is the doselimiting effect and PPAR? activation results in the chemicalmediated toxicity
D) ROR activation results in chemicalmediated toxicity and PPAR? activation results in the doselimiting effect
E) Other ROR drugs will result in increased insulin sensitivity
What happens to transcription at the lac operon when lactose is absent and present explain your answer.
Hermann Kolbe's synthesis of an organic compound, acetic acid, from inorganic substances that had been prepared straight from pure elements was an important milestone for what reason.What piece of evidence contradicts this claim.
If there are 20 amino acids commonly found in protiens, how many different dipeptides are there.
Assume that the habitat is fairly uniform, how various nests would he expect to be in the entire 200-acre preserve.
Assume that there are 63 different naturally occurring amino acids. If all 64 possible combinations of bases for a codon resulted in coding for 63 different amino acids and one stop codon, which of the next mutations would NOT be possible.
Examine the major stages of sea urchin development with reference to your series of detailed drawings and observational notes. How did the embryonic cells compare in size with the original gamete cells? State reasons such a difference may exist.
What would happen if one were to inject both the R strain and heat-killed S strains into a host organism such as the mouse.
A form of vitamin D-resistant rickets, known as hypophosphatemia, is inherited as an x-linked dominant trait. If a male with hypophosphatemia, marries a normal female, which predictions concerning their potential progeny would be true.
Oxygen is the final electron acceptor of this pathway. Glycolysis is the only energy yielding step of this pathway.
After verifying that the protein complex was incorporated into liposomes, you put in NADH and incubate at 37°C. You are dismayed to view no color change in the pH indicator dye.
Discuss embryonic stem cell invitro methord in which transgenic animal were generated and efficient show how homologous recombination happening?
A cross is made between tall, red flowered plants and short, white flowered plants. Tall and red are dominant traits. Determine what the expected phenotypic ratios of the f1 and f2 generations should be.
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