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Analyse a toxicological event produce a technical report

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Reference no: EM131504698

Toxicology - Report assignment

This assessment task requires you to work individually to apply your understanding of toxicology, to analyse a toxicological event/scenario and produce a technical report. This assignment is meant to assist you to consolidate your knowledge of toxicology in the context of a case study. It will require you to find toxicological information and to interpret according to principles that you have learned in this unit.

You are required to:

- choose one scenario (from those attached), and analyse the data/information provided;

- nominate the audience that the report is directed to;

- research current literature;
- create a professional written technical report, meeting industry standards for a professional audience; and

The elective topics and the core topics are to be used as sources of information and important toxicological principles.
It is important that you do not just state information - you must analyse/discuss/comment on data information you use and relate back to the specific scenario question or task - you are providing expert advice so need to analyse the information to provide advice to the stakeholder.

General Instructions

The final topics in this unit are designed to provide background information on a number of applied areas of toxicology. You need not study all of these but should use them to help you understand these professional areas and to consolidate your knowledge of toxicology.

For your final assignment, there are four case studies to choose from. You should select just one of these to complete. Whichever you chose, it will provide the same opportunity to bring together the basic principles of toxicology introduced throughout this unit and to learn how to apply this knowledge to a real world problem in a professional context.

Report

The assignment must be submitted as a report (2,000 words not including references) written for a specified audience and purpose (see the details in the relevant cases studies). Please read the specific instructions for each case study. The report should have the following section headings and relevant content.
- Your name and student number
- Case Study Title
- Abstract
Write a very short summary of your report
- Suspected toxic substance
Give the chemical and common name (if any) of the substance and CAS number
(CAS Registry Numbers are unique numerical identifiers assigned by the Chemical Abstracts Service to every chemical described in the open scientific literature).

- ADME
List the possible routes of uptake of this substance, the relevant metabolites if any, and the routes of excretion. Indicate the half-life (or lives) of the substance and relevant toxic metabolites in the body, and indicate if it can accumulate in the body.

- Toxicology of the suspected substance
Summarise the toxic effects of the substance, the target organs and the toxic mechanism. Give the acute and toxic doses (eg LD50, LC50, SHD, chronic toxic doses as relevant).
Indicate the time course of the effects - for example are they delayed and by how long.

- Conclusion
Does the information support the details in the case study or not

- Other Information
Provide specific information suitable for the specialist toxicologists relevant to the case study you chose (see the specific instructions for each case study).

- References

All information included in the report must be properly referenced. Any quotations must be identified in italics or quotation marks and the source included in the references.

Length - 2,000 words for the report

Attachment:- Case Study.rar

Verified Expert

We have to take up a case study on environmental toxicology due to lead. To do so we need to first understand how lead can be toxic to every aspect of the environment, whether it's the organisms or the biomes. Also, we need to to find toxicology and toxicokinetics of Lead. By understanding the impact of lead on the environment, we can also understand the steps to be taken to avoid environmental toxic impact due to lead.

Reference no: EM131504698

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Reviews

inf1504698

6/16/2017 4:57:17 AM

What an incredible paper! Many thanks to you for such great work, I'll unquestionably return once more. Magnificent employment! They author was amazingly quick and made all rectifications without any issues or holds.

inf1504698

6/16/2017 4:56:38 AM

Objectives This topic outlines the passage of toxins through the human body; their absorption, distribution, metabolism and elimination (ADME). Areas covered include: ? absorption via the respiratory tract, skin and gastro-intestinal tract; ? distribution within the body; ? metabolism (biotransformation); ? mechanisms of action; ? elimination; and ? accumulation. Toxic chemicals can enter the body in a number of ways. These may involve: ? ingestion via the gastrointestinal tract (by eating or drinking), ? inhalation through the respiratory tract ? absorption through the skin (some substances can permeate through the skin) ? injection (for example by a hypodermic or by a snake or insect bite) There are a few minor routes of entry including through the eyes and even through the ear canal.

inf1504698

6/16/2017 4:56:16 AM

Objectives After studying this topic you should: ? Be able to explain the concept and importance of toxicokinetics ? Understand linear elimination kinetics and be able to apply these to simple situations such as alcohol intoxication ? Understand and be able to apply simple first order kinetics, for example in the case of carbon monoxide poisoning ? Be able to calculate the half-life of a toxic substance using a graphical technique ? Be able to determine if a substance has single compartment or two-compartment kinetics using a graphical technique. When pharmacologists are describing the rates (speed) of uptake and excretion of a pharmaceutical they talk about the "pharmacokinetics" of the substance. "Pharma-" comes from the Greek "pharmakon", meaning drug and "kinetics" is the quantitative study of rates of change. When toxicologists are describing the rates of uptake and excretion of toxic substances they talk about the "toxicokinetics" of the substance. Pharmacokinetics and toxicokinetics are essentially the same.

inf1504698

6/16/2017 4:55:38 AM

some of my lecture slides 23582730_1Topic 3 - ADME.pdf 23582730_2Topic 4-Toxicokinetics.pdf 23582730_3Topic 5 - Interactions.pdf The aim of this chapter is to examine the basic chemical interactions that occur between toxic substances and biological molecules; these are the fundamental first steps in toxicity. After studying this topic you should: ? Understand solvent/solute interactions in toxicology including the effects of lipidsoluble compounds on cell membranes and osmotic effects; ? Understand some of the effects associated with abnormal tissue pH; ? Appreciate that many biological molecules are prone to oxidation, including membrane phospholipids and metal centres in functional proteins; ? Understand the role of reversible binding in toxicology including "complex" formation, ? Understand the importance of irreversible binding and the formation of "adducts" in toxicology

len1504698

5/23/2017 3:18:39 AM

references should be harvard. word count should be without references. could you please add charts and tables. i attached some of my lectures with this. Abstract 10% Obtaining relevant information relating to the headings above 20% Correct referencing of all information obtained (this is essential) 10% Analysing/commenting/interpreting the information obtained in the context of the case study 35% Correctly applying the concepts that you have learned in this unit 10% Writing concise notes that correctly summarise the information 10% Conclusion as to your advice 5%

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