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Early in development, most human cells turn off expression of an essential component of telomerase, the enzyme responsible for addition of telomere repeat sequences (5' TTAGGG 3') to the ends of chromosomes. Thus, as our cells proliferate, their telomeres get shorter and shorter, but are normally lost over the course of a lifetime. If cells are removed from the body and grown in culture, they ultimately enter a state of replicative senescence and stop dividing when their telomeres get too short. By contrast, most tumor cells, in humans and in cell culture, express active telomerase allowing them to maintain their telomeres and grow beyond the normal limit imposed by senescence. Anticipating a universal cure for cancer, you set up a company to screen chemical ‘libraries' for telomerase inhibitors. The company share price takes a tumble, when a rival group generates a strain of mice from which the telomerase genes have been deleted. These mice breed happily for several generations, but by the 6th generation (when their telomeres are much shorter than those of normal mice), they have a greatly increased tendency to die of tumors. The tumors tend to arise in tissues that show high proliferation rates, such as testis, skin, and blood. Why has this observation shaken the confidence of your investors? Is there a flaw in your hypothesis?
A breaking buffer contains 10mM Tris, pH 8.0, 150mM Nacl. The elution buffer is breaking buffer that also contains 300mM imidazole.
A friend of yours is wearing a bright red shirt. In terms of properties of light and pigments, describe why the shirt appears red to you.
how to Analysis of base composition from DNA. Using this data predict the % of adenine. If the same were detected in Tobacco Mosaic Virus [TMV], will it be possible to predict the % of adenine. This job gives reasons.
Predict equilibrium potentials E K and E Na at a temperature of 13 o C. Suppose that the Na permeability of the cell membrane is 1/50 that of the K permeability, predict the resting potential, E m , assuming that Cl is in equilibrium.
What genotypic frequencies are expected at birth in the next generation. How much change has there been in the frequency of the B allele.
Cartenoids are frequently found in foods that are considered to have antioxident properties in human nutrition. What related function do they have in plants.
A pregnant woman is worried about the chances of her child having hemophilia as both she and her husband have paternal grandfathers with hemophilia.What are the likely genotypes of the couple
Write a scientific review of membrane proteins
You are tasked with analyzing the transmission of a genetic disease through several generations. Males are indicated by square, females by circles.
There is a general agreement that life should have evolved in the oceans originally and only much later invaded land. What factors of the physical environment on the early and evolving Earth support these ideas? Changes in which of these factors were..
Discuss and explain the role of antidiuretic hormone and aldosterone in the maintenance of blood pressure. Fairly detailed please.
Determining Diffusivity of Solutes in a Liquid Compute the diffusion coefficient of a protein macromolecule bovine scrum albumin (BSA) at 23degreeC.
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