Activation of growth factor signaling pathway

Reference no: EM133200059 , Length: 4 Pages

Assignment - More Cell Signaling

Activation of the Growth Factor Signaling pathway ultimately leads to controlled growth and division of a cell. Many different mutations have been identified in this pathway that ultimately lead to cancer. The goal of this assignment is for you to imagine what could go wrong in the pathway that would make the pathway more active than it normally would be so that cancer would be the outcome.

There are 10 numbered steps on the pathway diagram.Three have already been selected for you. You get to select one of the other seven remaining. For each step, I want you to describe a mutation in each of the steps that would result in overstimulation(becomes more active) of the pathway such that it would result in excess cell proliferation (cancer).

1. Step 2.

Describe what is occurring at this step when things are normal.

Describe a way that this step could become broken (mutated) such that it results in continued growth when it should not or more growth than normal.

2. Step 5.

Describe what is occurring at this step when things are normal.

Describe a way that this step could become broken (mutated) such that it results in continued growth when it should not or more growth than normal.

3. Step 7.

Describe what is occurring at this step when things are normal.

Describe a way that this step could become broken (mutated) such that it results in continued growth when it should not or more growth than normal.

4. Step ________.

Describe what is occurring at this step when things are normal.

Describe a way that this step could become broken (mutated) such that it results in continued growth when it should not or more growth than normal.

Attachment:- Growth Sigalling Pathway.rar

Reference no: EM133200059

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