Solution-Acidic pka values of the respective hydroxyl

Acidic pka values of the respective hydroxyl products

Reference no: EM13279880

Assignment One:

Heroin is 3, 6-diacetylmorphine. Heroin is 2-3 times more potent than morphine.

In vitro and in vivo, to which product does heroin hydrolyze first, (3- or 6-acetylmorphine), and why?

Hint:What are the acidic pKa values of the respective hydroxyl products? Look up the structures on the internet or use the UF library online e-journals.

Assignment Two:

Acetyl sulfisoxazole, is readily hydrolyzed in vivo to sulfisoxazole. On the other hand, the acyl group in amikacin, is stable to hydrolysis in vivo. Both acetylsulfisoxazole and amikacin are acyl derivatives where the acyl group is attached to nitrogen.
Why is one stable and the other not?

Hint:What are the acidic pKa values of the respective N-H groups formed on hydrolysis. Look up the structures on the internet or use the UF library online e-journals.

Reference no: EM13279880

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Acidic pka values of the respective hydroxyl products

Reference no: EM13279880

Reference no: EM13279880

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