Acetyl-coa carboxylase is a key regulatory enzyme in the

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Acetyl-CoA carboxylase is a key regulatory enzyme in fatty acid synthesis. Early studies on the molecular properties of this enzyme purified from avian liver produced the data given in table.

Table: Molecular properties of avian acetyl-CoA carboxylase

Treatments

Sedimentation coefficient (S)

Molecular mass (kDa)

Catalytic activity (arbitrary units)

10 mM citrate

55-59

4000-8000

35

0.5M NaCl, pH8-9

13.1

410

2.5

a) Explain the results shown in table in terms of the molecular structure of acetyl-CoA carboxylase and comment on their apparent physiological significance.

b) Which cellular compartment would you expect the acetyl-CoA carboxylase activity to have been observed in and why?

Reference no: EM13454754

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