Urea or Carbamide 
Urea may be considered as diamide of an unstable and dibasic carbonic acid from which both the hydroxyl groups have been replaced by -NH2 groups.
- First time isolated from urine in 1773 by Roulle and hence the name urea was given.
- It was the first organic element synthesised in the laboratory from inorganic material (by heating a mixture of ammonium sulphate and potassium cyanate) by Wohler in 1828.
- This preparation gave a death blow to Vital force theory.
- It is the final decomposition product of protein's metabolism in man and mammals and is excreted along with urine.
- Adults excrete about 30 grams of urea per day in the urine.
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