Antipyretic: Antipyretic is a drug which is responsible for lowering the temperature of feverish object. The central nervous system, particularly the hypothalamus, takes an important role in maintaining the balance between the heat production and heat loss in order to regulate the body temperature. Hypothalamus is, thus, called as the thermostat of the body.
The antipyretic drug helps to reset the thermostat at normal temperature. Heat development is not inhibited but heat loss is increased by increased peripheral blood flow which increases the rate of perspiration. This reflects body to lose heat and subsequently lowers the body temperature.
Aspirin is an important antipyretic. The other antipyretics are paracetamol, phenacetin, phenyl butazone and novalgin.
Aspirin should not be taken empty stomach. Some mans are allergic to aspirin.
The usual allergic reaction is lowering of blood pressure, profuse sweating, rashes on skin, intense thirst, vomiting and nausea. Sodium and calcium salts of aspirin are more soluble and less harmful.
The derivatives of p-aminophenol are used as antipyretic. The basic restriction of these derivatives is that they may act on red blood cells and thus, they can be injurious in moderate doses.
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