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Molecular Structure and Chemical Forces.

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  • "Cell Biology Problem Set 2Molecular structure and chemical forces.The United States is currently in the middle of a heroin addiction epidemic, which hasresulted in an elevation in the number of deaths from heroin overdose (especially amongyoung adul..

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  • "Cell Biology Problem Set 2Molecular structure and chemical forces.The United States is currently in the middle of a heroin addiction epidemic, which hasresulted in an elevation in the number of deaths from heroin overdose (especially amongyoung adults).Heroin is derived from natural metabolite produced by the opium poppy,the pain-killing compound morphine.Morphine (below) is an example of a product ofsecondary metabolism (aspects of metabolism specific to an organism).Morphine and its derivatives such as heroin bind to cell membrane receptors called mu- opiod receptors.A morphine like compound (thered and green spacefilling molecule) is shownbound to this receptor in the diagram below.This receptor protein is an example of a G- protein coupled receptors (GPCRs), which wewill cover later in this course.[Nature. 2012.485(7398): 321 – 326.]StructureMorphine is a ligand for the mu-opiod receptor protein.Use your knowledge of chemistry(particularly organic chemistry) to identify as many aspects of thismo l e c u l e ’ s structure asyou can.You can print this handout and draw on the diagram.You can submit youranswers using an image saved from your cell phone (or paste it into this Word documentand submit it via the assignment link.A great place on the web to get information about chemical and physical properties ofchemical compounds is PubChem.You can find more information and different diagrams ofmorphine at: https://pubchem.ncbi.nlm.nih.gov/compound/morphine.ANS.-Different aspects of structure of morphine -----"

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